O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine

Base Information

• Chemical Name: O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine
• CAS No.: 1028432-04-3
• Molecular Formula: C13H23NO3SSi
• Molecular Weight: 301.482
• Mol file: 1028432-04-3.mol

Synonyms:O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine;TsNHOTBDMS;TsNHOTBS;N-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-4-methylbenzenesulfonamide

Chemical Property of O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine

Chemical Property:

• Melting Point: 90-96°C
• Boiling Point: 352.3±35.0 °C(Predicted)
• PKA: 6.54±0.40(Predicted)
• PSA: 63.78000
• Density: 1.072±0.06 g/cm3(Predicted)
• LogP: 4.68180
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

O-(tert-Butyldimethylsilyl)-N-tosylhydroxylamine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine

There total 3 articles about O-(tert-ButyldiMethylsilyl)-N-tosylhydroxylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

p-toluenesulfonylhydroxylamine (1593-60-8) + tert-butyldimethylsilyl chloride (18162-48-6) → N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide (1028432-04-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201605152

Reference yield: 69.0%

tert-butyldimethylsilyl chloride (18162-48-6) + p-toluenesulfonyl chloride (98-59-9) → N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide (1028432-04-3)

Guidance literature:

tert-butyldimethylsilyl chloride; With hydroxylamine hydrochloride; In N,N-dimethyl-formamide; for 0.5h; Cooling with ice;

With triethylamine; In N,N-dimethyl-formamide; at 10 ℃;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; at 10 ℃;

DOI:10.15227/orgsyn.089.0480

Reference yield:

O-(tert-butyldimethylsilanyl)hydroxylamine (41879-39-4) + p-toluenesulfonyl chloride (98-59-9) → N-(tert-butyldimethylsilyloxy)-4-methylbenzenesulfonamide (1028432-04-3)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol800677p

upstream raw materials:

O-(tert-butyldimethylsilanyl)hydroxylamine

p-toluenesulfonyl chloride

tert-butyldimethylsilyl chloride

p-toluenesulfonylhydroxylamine

Downstream raw materials:

C₃₀H₄₇NO₅SSi

C₂₀H₂₈N₂O₅SSi

C₂₂H₃₉NO₃SSi

C₁₉H₂₉NO₃SSi

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