N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers)

Base Information

• Chemical Name: N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers)
• CAS No.: 444577-70-2
• Molecular Formula: C26H25NO3
• Molecular Weight: 399.4816
• Mol file: 444577-70-2.mol

Synonyms:N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers);α-(2-Methyl-1-oxopropyl)-γ-oxo-N,β-diphenylbenzenebutanaMide

Chemical Property of N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 629.052°C at 760 mmHg
• Flash Point: 195.947°C
• PSA: 66.73000
• Density: 1.174g/cm³
• LogP: 5.78260
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Sonicated), Methanol (Slightly, Sonicated)

Purity/Quality:

NLT 98% ^*data from raw suppliers

N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A byproduct of Atorvastatin intermediate production, also an intermediate for the synthesis of Atorvastatin impurities

Technology Process of N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers)

There total 1 articles about N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

benzaldehyde (100-52-7) + 4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide (222320-29-8) → 4-methyl-3-oxo-2-(2-oxo-1,2-diphenylethyl)-N-phenylpentanamide (444577-70-2)

Guidance literature:

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine; In ethanol; at 80 ℃; for 24h;

DOI:10.1135/cccc20080229

Reference yield: 60.0%

4-methyl-3-oxo-2-(2-oxo-1,2-diphenylethyl)-N-phenylpentanamide (444577-70-2) + tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (125971-86-0,125995-13-3) → tert-butyl (4R,6R)-6-{2-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate (1105067-91-1)

Guidance literature:

With Trimethylacetic acid; In n-heptane; toluene; for 30h; Heating;

DOI:10.1135/cccc20080229

upstream raw materials:

benzaldehyde

4-Methyl-3-oxo-N-phenyl-2(phenylmethylene)pentanamide

Downstream raw materials:

tert-butyl (4R,6R)-6-{2-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 444577-70-2 N,3-Diphenyl-2-(2-methyl-1-oxopropyl)4-oxo-N-benzenebutanamide (Mixture of Diastereomers)

Send

Send

Metric Ton KG G Pound L ML

Send

Send