Defluoro Atorvastatin Acetonide tert-Butyl Ester

Base Information

• Chemical Name: Defluoro Atorvastatin Acetonide tert-Butyl Ester
• CAS No.: 1105067-91-1
• Molecular Formula: C₄₀H₄₈N₂O₅
• Molecular Weight: 636.832
• Mol file: 1105067-91-1.mol

Synonyms:Defluoro Atorvastatin Acetonide tert-Butyl Ester;(4R,6R)-2,2-DiMethyl-6-[2-[2-(1-Methylethyl)-4,5-diphenyl-3-[(phenylaMino)carbonyl]-1H-pyrrol-1-yl]ethyl]-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester

Chemical Property of Defluoro Atorvastatin Acetonide tert-Butyl Ester

Chemical Property:

• PSA: 82.28000
• LogP: 9.61390
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

DefluoroAtorvastatinAcetonidetert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: An intermediate in the preparation of Atorvastatin impurities

Technology Process of Defluoro Atorvastatin Acetonide tert-Butyl Ester

There total 1 articles about Defluoro Atorvastatin Acetonide tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-methyl-3-oxo-2-(2-oxo-1,2-diphenylethyl)-N-phenylpentanamide (444577-70-2) + tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate (125971-86-0,125995-13-3) → tert-butyl (4R,6R)-6-{2-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate (1105067-91-1)

Guidance literature:

With Trimethylacetic acid; In n-heptane; toluene; for 30h; Heating;

DOI:10.1135/cccc20080229

Reference yield:

tert-butyl (4R,6R)-6-{2-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate (1105067-91-1) → (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-phenylcarbamoyl-pyrrol-1-yl)-heptanoic acid (433289-84-0)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 6h;

DOI:10.1135/cccc20080229

upstream raw materials:

4-methyl-3-oxo-2-(2-oxo-1,2-diphenylethyl)-N-phenylpentanamide

tert-butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Downstream raw materials:

(3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-phenylcarbamoyl-pyrrol-1-yl)-heptanoic acid

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