tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

• Chemical Name: tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS No.: 1430564-15-0
• Molecular Formula: C₂₂H₂₆N₂O₄
• Molecular Weight: 382.459
• Mol file: 1430564-15-0.mol

Synonyms:tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property of tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 1 articles about tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

(4-((methoxycarbonyl) amino)phenyl)boronic acid (850567-96-3) + 5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (215184-78-4) → tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1430564-15-0)

Guidance literature:

With potassium phosphate; palladium diacetate; tricyclohexylphosphine; In water; toluene; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield:

tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1430564-15-0) → C17H18N2O2

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 48h;

Reference yield:

tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1430564-15-0) → (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-(methoxycarbonylamino)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid (1430561-63-9)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 48 h

2: manganese(IV) oxide

3: ethanol / 24 h / Reflux

4: trifluoroacetic acid / dichloromethane

With manganese(IV) oxide; trifluoroacetic acid; In ethanol; dichloromethane; 3: |Ugi Condensation;

upstream raw materials:

(4-((methoxycarbonyl) amino)phenyl)boronic acid

5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Downstream raw materials:

(E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-(methoxycarbonylamino)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

(E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate