(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Base Information

• Chemical Name: (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate
• CAS No.: 1430561-78-6
• Molecular Formula: C₃₄H₂₆ClF₂N₇O₄
• Molecular Weight: 670.075
• Mol file: 1430561-78-6.mol

Synonyms:(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Chemical Property of (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

There total 5 articles about (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-72-0) → (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-77-5) + (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-78-6)

Guidance literature:

With pyridine; carbon dioxide; In methanol; ethanol; under 75007.5 Torr; Resolution of racemate;

Reference yield:

5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (215184-78-4) → (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-77-5) + (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-78-6)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C / Inert atmosphere; Sealed tube

2: trifluoroacetic acid / dichloromethane / 48 h

3: manganese(IV) oxide

4: ethanol / 24 h / Reflux

5: pyridine; carbon dioxide / ethanol; methanol / 75007.5 Torr / Resolution of racemate

With pyridine; manganese(IV) oxide; potassium phosphate; carbon dioxide; palladium diacetate; trifluoroacetic acid; tricyclohexylphosphine; In methanol; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Ugi Condensation;

Reference yield:

(4-((methoxycarbonyl) amino)phenyl)boronic acid (850567-96-3) → (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-77-5) + (S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate (1430561-78-6)

Guidance literature:

Multi-step reaction with 5 steps

1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C / Inert atmosphere; Sealed tube

2: trifluoroacetic acid / dichloromethane / 48 h

3: manganese(IV) oxide

4: ethanol / 24 h / Reflux

5: pyridine; carbon dioxide / ethanol; methanol / 75007.5 Torr / Resolution of racemate

With pyridine; manganese(IV) oxide; potassium phosphate; carbon dioxide; palladium diacetate; trifluoroacetic acid; tricyclohexylphosphine; In methanol; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Ugi Condensation;

upstream raw materials:

5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

(4-((methoxycarbonyl) amino)phenyl)boronic acid

tert-butyl 5-(4-(methoxycarbonylamino)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

(E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate