(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Base Information

Chemical Name:(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate
CAS No.:1430561-77-5
Molecular Formula:C₃₄H₂₆ClF₂N₇O₄
Molecular Weight:670.075
Hs Code.:

(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Synonyms:(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

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Chemical Property of (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

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Technology Process of (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

There total 5 articles about (R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430561-72-0
(E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

: 1430561-77-5
(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

: 1430561-78-6
(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Guidance literature:: With pyridine; carbon dioxide; In methanol; ethanol; under 75007.5 Torr; Resolution of racemate;

Reference yield:

: 215184-78-4
5-bromo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 1430561-77-5
(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

: 1430561-78-6
(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C / Inert atmosphere; Sealed tube

2: trifluoroacetic acid / dichloromethane / 48 h

3: manganese(IV) oxide

4: ethanol / 24 h / Reflux

5: pyridine; carbon dioxide / ethanol; methanol / 75007.5 Torr / Resolution of racemate

With pyridine; manganese(IV) oxide; potassium phosphate; carbon dioxide; palladium diacetate; trifluoroacetic acid; tricyclohexylphosphine; In methanol; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Ugi Condensation;

Reference yield:

: 850567-96-3
(4-((methoxycarbonyl) amino)phenyl)boronic acid

: 1430561-77-5
(R,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

: 1430561-78-6
(S,E)-methyl 4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1-((4-fluorophenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-5-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / water; toluene / 12 h / 100 °C / Inert atmosphere; Sealed tube

2: trifluoroacetic acid / dichloromethane / 48 h

3: manganese(IV) oxide

4: ethanol / 24 h / Reflux

5: pyridine; carbon dioxide / ethanol; methanol / 75007.5 Torr / Resolution of racemate

With pyridine; manganese(IV) oxide; potassium phosphate; carbon dioxide; palladium diacetate; trifluoroacetic acid; tricyclohexylphosphine; In methanol; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Ugi Condensation;