ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate

Base Information

• Chemical Name: ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate
• CAS No.: 66129-60-0
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.294
• Hs Code.: 2922390090
• Mol file: 66129-60-0.mol

Synonyms:ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate;Ethyl 2-benzoyl-3-(dimethylamino)acrylate, tech;Ethyl 2-benzoyl-3-(dimethylamino)prop-2-enoate, Ethyl 2-[(dimethylamino)methylene]-3-oxo-3-phenylpropanoate

Chemical Property of ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate

Chemical Property:

• Melting Point: 63-65 °C
• Boiling Point: 30 °C(Press: 0.1 Torr)
• PKA: 3.51±0.70(Predicted)
• PSA: 46.61000
• Density: 1.103±0.06 g/cm3(Predicted)
• LogP: 1.87790

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-benzoyl-3-(dimethylamino)acrylate, technical grade ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate

There total 5 articles about ethyl-3-(diMethylaMino)-2-(phenylcarbonyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate (66129-60-0)

Guidance literature:

at 110 ℃; for 0.666667h; Microwave irradiation;

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-ethyl 2-(N,N-dimethylaminomethyliden) benzoylacetate (66129-60-0)

Guidance literature:

In toluene; at 100 - 120 ℃; for 24h;

DOI:10.1039/c2md00273f

Reference yield:

phenylglyoxylic acid ethyl ester (1603-79-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate (66129-60-0)

Guidance literature:

In toluene; for 2h; Reflux;

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

N,N-dimethyl-formamide dimethyl acetal

ethyl acetoacetate

benzoyl chloride

Downstream raw materials:

ethyl 3-(benzoylamino)-6-phenyl-2-oxo-2H-pyran-5-carboxylate

2-methyl-4-phenyl-pyrimidine-5-carboxylic acid ethyl ester

N-(2-benzoyl-2-ethoxycarbonylvinyl-1)glycine

N-(2-benzoyl-2-ethoxycarbonylvinyl-1)methionine

Refernces

• 1、 Rohde, Jason M.,Karavadhi, Surendra,Pragani, Rajan,Liu, Li,Fang, Yuhong,Zhang, Weihe,McIver, Andrew,Zheng, Hongchao,Liu, Qingyang,Davis, Mindy I.,Urban, Daniel J.,Lee, Tobie D.,Cheff, Dorian M.,Hollingshead, Melinda,Henderson, Mark J.,Martinez, Natalia J.,Brimacombe, Kyle R.,Yasgar, Adam,Zhao, Wei,Klumpp-Thomas, Carleen,Michael, Sam,Covey, Joseph,Moore, William J.,Stott, Gordon M.,Li, Zhuyin,Simeonov, Anton,Jadhav, Ajit,Frye, Stephen,Hall, Matthew D.,Shen, Min,Wang, Xiaodong,Patnaik, Samarjit,Boxer, Matthew B.. "Discovery and Optimization of 2 H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer". . p. 4913 - 4946. Retrieved 2021/05/07.
• 2、 Bharath, Yarlagadda,Rao, Mandava V. Basaveswara,Pal, Manojit. "Ultrasound assisted synthesis of 2-alkynyl pyrazolo[1,5-a]pyrimidines as potential anti-cancer agents". . p. 1206 - 1214. Retrieved 2017/11/14.