5-hydroxypridine-3-boronic acid

Base Information

• Chemical Name: 5-hydroxypridine-3-boronic acid
• CAS No.: 1208308-11-5
• Molecular Formula: C5H6BNO3
• Molecular Weight: 138.919
• Hs Code.: 2934999090
• Mol file: 1208308-11-5.mol

Synonyms:5-hydroxypridine-3-boronic acid;(5-Hydroxypyridin-3-yl)boronic acid;5-Hydroxypyridine-3-boronic acid

Chemical Property of 5-hydroxypridine-3-boronic acid

Chemical Property:

• Boiling Point: 530.5±60.0 °C(Predicted)
• PKA: 3.73±0.10(Predicted)
• PSA: 73.58000
• Density: 1.42±0.1 g/cm3(Predicted)
• LogP: -1.53300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(5-Hydroxypyridin-3-yl)boronic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Hydroxypyridine-3-boronic Acid was used to study imidazolopyrimidines as dual PI3-kinase/mTOR inhibitors.

Technology Process of 5-hydroxypridine-3-boronic acid

There total 1 articles about 5-hydroxypridine-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromopyridine-3-ol (74115-13-2) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-3-ol (1171891-35-2) + (5-hydroxypyridin-3-yl)boronic acid (1208308-11-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; for 29h; Inert atmosphere; Heating;

DOI:10.1021/jm800851u

Reference yield:

(5-hydroxypyridin-3-yl)boronic acid (1208308-11-5) + 4-chloro-2-iodo-1-methoxybenzene (52807-27-9) → C12H10ClNO2

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 100 ℃;

Reference yield:

(5-hydroxypyridin-3-yl)boronic acid (1208308-11-5) + C8H8BrClO (59106-55-7) → C13H12ClNO2

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 100 ℃;

upstream raw materials:

5-bromopyridine-3-ol

bis(pinacol)diborane

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