4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine

Base Information

Chemical Name:4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine
CAS No.:1256256-24-2
Molecular Formula:C₁₅H₂₂BNO₃
Molecular Weight:275.156
Hs Code.:2934999090
Mol file:1256256-24-2.mol

Synonyms:4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine;4-Methyl-2,3-dihydrobenzo-1,4-oxazine-6-boronic acid, pinacol ester;3,4-Dihydro-4-methyl-2H-1,4-benzoxazine-6-boronic acid, pinacol ester;3,4-Dihydro-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazine, 2-(3,4-Dihydro-4-methyl-2H-1,4-benzoxazin-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Suppliers and Price of 4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Methyl-2,3-dihydrobenzo-1,4-oxazine-6-boronicacidpinacolester
100mg
$ 285.00

TRC
4-Methyl-2,3-dihydrobenzo-1,4-oxazine-6-boronicacidpinacolester
50mg
$ 200.00

Crysdot
4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 95+%
1g
$ 706.00

Chemenu
4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 95%
1g
$ 713.00

Total 9 raw suppliers

Chemical Property of 4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine

Chemical Property:

PSA：30.93000
LogP:1.87940

Purity/Quality:

98%min ^*data from raw suppliers

4-Methyl-2,3-dihydrobenzo-1,4-oxazine-6-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine

There total 4 articles about 4-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77901-22-5
4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 73183-34-3
bis(pinacol)diborane

: 519054-54-7
4-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine

: 1256256-24-2
4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 1583286-76-3
C₁₅H₂₂BNO₃

Guidance literature:: With iridium catalyst; Overall yield = 79 %Chromat.; regioselective reaction;
DOI:10.1126/science.1248042

Reference yield:

: 188947-79-7
6-bromo-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 73183-34-3
bis(pinacol)diborane

: 1256256-24-2
4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; Inert atmosphere;

Reference yield:

: 105655-01-4
6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine

: 1256256-24-2
4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 70 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;