Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo-

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo-
• CAS No.: 1310250-12-4
• Molecular Formula: C₇H₄N₄O₂
• Molecular Weight: 176.134
• Hs Code.: 2933990090
• Mol file: 1310250-12-4.mol

Synonyms:Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo-

Chemical Property of Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo-

Chemical Property:

• PSA: 94.18000
• LogP: -0.40012

Purity/Quality:

98%min ^*data from raw suppliers

7-Hydroxy-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo-

There total 2 articles about Pyrazolo[1,5-a]pyriMidine-3-carbonitrile, 4,5-dihydro-7-hydroxy-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.38%

3-Amino-4-cyanopyrazole (16617-46-2,882231-01-8) + diethyl malonate (105-53-3) → 5,7-dihydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (1310250-12-4)

Guidance literature:

With sodium ethanolate; In ethanol; for 10h; Reflux;

Reference yield: 35.0%

3-amino-4-cyano-2H-pyrazole (16617-46-2) + diethyl malonate (105-53-3) → 5,7-dihydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (1310250-12-4)

Guidance literature:

With sodium ethanolate; In ethanol; at 90 ℃; for 24h;

Reference yield: 74.42%

5,7-dihydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile (1310250-12-4) → 5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile (845895-95-6)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; at 90 ℃; for 3h;

upstream raw materials:

3-Amino-4-cyanopyrazole

diethyl malonate

3-amino-4-cyano-2H-pyrazole

Downstream raw materials:

5,7-dichloropyrazolo[1,5-a]pyrimidine-3-carbonitrile

2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethyl methanesulfonate

N-(5-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-((2-hydroxyethyl)(methyl)amino)phenyl) acetamide

tert-butyl 2-((2-acetamido-4-(3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)phenyl)(methyl)amino)ethylcarbamate

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