Anirolac

Base Information

• Chemical Name: Anirolac
• CAS No.: 66635-85-6
• Molecular Formula: C16H15NO4
• Molecular Weight: 285.2946
• Hs Code.: 2933990090
• Mol file: 66635-85-6.mol

Synonyms:Anirolacum [Latin];5-(p-methoxybenzoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acid;Anirolaco [Spanish];Anirolacum;Anirolac (USAN/INN);ANIROLAC;Anirolaco;5-(4-methoxybenzoyl)-2,3-dihydropyrrolizin-1-carboxylic acid;5-(para-methoxy)-benzoyl-1,2-dihydro-3H-pyrrolo(1,2-a)-pyrrole-1-carboxylic acid;

Chemical Property of Anirolac

Chemical Property:

• Vapor Pressure: 3.58E-12mmHg at 25°C
• Boiling Point: 532.6°Cat760mmHg
• PKA: 4.27±0.20(Predicted)
• Flash Point: 275.9°C
• PSA: 68.53000
• Density: 1.33g/cm³
• LogP: 2.29960

Purity/Quality:

Anirolac ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antiinflammatory; analgesic. Anirolac is a nonsteroidal anti-inflammatory drug with analgesic properties. Study suggests that pain relief due to Anirolac is equivalent to that of Naproxen (N377520).
• Therapeutic Function: Antiinflammatory, Analgesic

Technology Process of Anirolac

There total 4 articles about Anirolac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

isopropyl 5-p-methoxybenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (66635-77-6) → Anirolac (66635-85-6)

Guidance literature:

With potassium carbonate; In methanol; water; for 0.33h; Heating;

DOI:10.1021/jm00146a011

Reference yield:

N,N-dimethyl-4-methoxybenzamide (7291-00-1) → Anirolac (66635-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 65 h

2: 85 percent / K₂CO₃ / methanol; H₂O / 0.33 h / Heating

With potassium carbonate; trichlorophosphate; In methanol; water;

DOI:10.1021/jm00146a011

Reference yield:

i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate (66635-71-0) → Anirolac (66635-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 1,2-dichloroethane, reflux, 1 h, 2.) 1,2-dichloroethane, reflux, 65 h

2: 85 percent / K₂CO₃ / methanol; H₂O / 0.33 h / Heating

With potassium carbonate; trichlorophosphate; In methanol; water;

DOI:10.1021/jm00146a011

upstream raw materials:

isopropyl 5-p-methoxybenzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

N,N-dimethyl-4-methoxybenzamide

i-propyl 1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate

Downstream raw materials:

2-diazo-1-[5-(4-methoxybenzoyl)-2,3-dihydropyrrolizin-1-yl]ethanone