3,6-Dimethylimidazo[2,1-b]thiazole

Base Information

• Chemical Name: 3,6-Dimethylimidazo[2,1-b]thiazole
• CAS No.: 25944-60-9
• Molecular Formula: C7H8N2S
• Molecular Weight: 152.22
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID40398635
• Nikkaji Number: J1.138.620B
• Wikidata: Q82200731
• Mol file: 25944-60-9.mol

Synonyms:3,6-Dimethylimidazo[2,1-b]thiazole;25944-60-9;Imidazo[2,1-b]thiazole, 3,6-dimethyl-;3,6-dimethylimidazo[2,1-b][1,3]thiazole;SCHEMBL3460400;DTXSID40398635;MFCD03556234;AKOS016001896;AS-77040;CS-0186750;D97369;A877424;Z56983119

Chemical Property of 3,6-Dimethylimidazo[2,1-b]thiazole

Chemical Property:

• PSA: 45.54000
• LogP: 2.01260
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 152.04081944
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

3,6-Dimethylimidazo[2,1-b]thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN2C(=CSC2=N1)C

Technology Process of 3,6-Dimethylimidazo[2,1-b]thiazole

There total 4 articles about 3,6-Dimethylimidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3,6-dimethyl-7H-imidazo<2,1-b>thiazolium bromide → 3,6-dimethylimidazo<2,1-b>thiazole (25944-60-9)

Guidance literature:

With sodium carbonate; In chloroform; at 20 ℃; for 0.333333h;

Reference yield: 48.0%

4-methylthiazol-2-ylamine (1603-91-4) + 1-bromoacetone (598-31-2) → 3,6-dimethylimidazo<2,1-b>thiazole (25944-60-9)

Guidance literature:

4-methylthiazol-2-ylamine; 1-bromoacetone; In acetone; for 3h; Reflux; Inert atmosphere;

With hydrogenchloride; In water; for 2h; Reflux; Inert atmosphere;

DOI:10.1021/ol2021109

Reference yield:

3-acetonyl-2-amino-4-methylthiazolium bromide → 3,6-dimethylimidazo<2,1-b>thiazole (25944-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / methanol / 3 h / Heating

2: 84 percent / 2M Na₂CO₃ / CHCl₃ / 0.33 h / 20 °C

With sodium carbonate; In methanol; chloroform;

upstream raw materials:

4-methylthiazol-2-ylamine

1-bromoacetone

Downstream raw materials:

C₁₃H₁₂N₂S

C₁₃H₁₁FN₂S

C₁₄H₁₄N₂OS

C₁₄H₁₄N₂S