D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL-

Base Information

• Chemical Name: D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL-
• CAS No.: 677299-15-9
• Molecular Formula: C21H22Cl4O5
• Molecular Weight: 496.215
• Mol file: 677299-15-9.mol

Synonyms:D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL-

Chemical Property of D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL-

Chemical Property:

• PSA: 57.15000
• LogP: 5.52450

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL-

There total 1 articles about D-RIBOFURANOSIDE,METHYL 3,5-BIS-O-[(2,4-DICHLOROPHENYL)METHYL]-2-C-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose (636581-82-3) + methylmagnesium bromide (75-16-1) → 3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-2-C-methyl-D-ribofuranose (677299-15-9)

Guidance literature:

3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose; methylmagnesium bromide; In diethyl ether; at -55 - -15 ℃; for 4h;

With water; In diethyl ether; at 0 - 20 ℃; for 0.5h;

Reference yield: 63.0%

3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-2-C-methyl-D-ribofuranose (677299-15-9) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine (443642-32-8)

Guidance literature:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In acetonitrile; at 20 ℃; for 4h;

3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-2-C-methyl-D-ribofuranose; With hydrogen bromide; In dichloromethane; acetic acid; acetonitrile; at 0 - 20 ℃; for 4.5h;

In acetonitrile; Alkaline conditions;

Reference yield:

3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-2-C-methyl-D-ribofuranose (677299-15-9) + 2,4-Dichlorobenzyl chloride (94-99-5) → C28H26Cl6O5 (1203549-21-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 70 ℃;

upstream raw materials:

3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

methylmagnesium bromide

Downstream raw materials:

4-chloro-7-[3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-methyl-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidine

C₂₈H₂₆Cl₆O₅

C₄₆H₅₁Cl₆N₅O₁₀

C₃₃H₂₈Cl₆N₄O₅

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