3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

Base Information

Chemical Name:3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose
CAS No.:636581-82-3
Molecular Formula:C₂₀H₁₈Cl₄O₅
Molecular Weight:480.172
Hs Code.:

Synonyms:3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

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Technology Process of 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

There total 1 articles about 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 636581-81-2
3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-ribofuranose

: 636581-82-3
3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

Guidance literature:: 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-ribofuranose; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 48.0%

: 636581-82-3
3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

: 16466-97-0,13254-27-8
1-propynylmagnesium bromide

: (3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-(prop-1-yn-1-yl)tetrahydrofuran-3-ol

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃; for 4.5h;

Reference yield:

: 636581-82-3
3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose

: 1044589-82-3
(2R,3R,4R,5R)-2-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 3 h / 0 °C

1.2: Cooling

2.1: hydrogen bromide; acetic acid / dichloromethane / 1.5 h / 20 °C

3.1: sodium hydride / acetonitrile / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: boron trichloride / dichloromethane / -78 °C

4.2: 0.5 h / 0 °C

5.1: ammonia / water / 5 h / 100 °C

With ammonia; hydrogen bromide; boron trichloride; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;