Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate

Base Information

• Chemical Name: Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate
• CAS No.: 156782-68-2
• Molecular Formula: C19H20FNO3
• Molecular Weight: 329.371
• Hs Code.: 2933399090
• Mol file: 156782-68-2.mol

Synonyms:Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property of Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 3.38380

Purity/Quality:

≥99% ^*data from raw suppliers

Benzyl4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate

There total 5 articles about Benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + 1-Bromo-4-fluorobenzene (460-00-4) → benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate (156782-68-2)

Guidance literature:

1-Bromo-4-fluorobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.583333h; Inert atmosphere;

benzyl 4-oxo-1-piperidinecarboxylate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 14.5h; Inert atmosphere;

DOI:10.1002/ejoc.201900498

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate (156782-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: Jones reagent / acetone / 0.25 h / at ice bath

3: tetrahydrofuran / 2 h / -78 - 20 °C

With jones reagent; triethylamine; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1016/j.tetlet.2005.10.015

Reference yield:

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) → benzyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate (156782-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 0.25 h / at ice bath

2: tetrahydrofuran / 2 h / -78 - 20 °C

With jones reagent; In tetrahydrofuran; acetone;

DOI:10.1016/j.tetlet.2005.10.015

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

4-fluorophenylmagnesium chloride

4-HYDROXYPIPERIDINE

1-(benzyloxycarbonyl)-4-hydroxypiperidine

Downstream raw materials:

benzyl 4-(4-fluorophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

4-(4-fluoro-phenyl)-3,4-dihydroxy-piperidine-1-carboxylic acid benzyl ester

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