5-Fluoro-2-formylbenzoic acid

Base Information

• Chemical Name: 5-Fluoro-2-formylbenzoic acid
• CAS No.: 920481-01-2
• Molecular Formula: C8H5FO3
• Molecular Weight: 168.124
• Hs Code.: 2916399090
• Mol file: 920481-01-2.mol

Synonyms:5-Fluoro-2-formylbenzoic acid

Chemical Property of 5-Fluoro-2-formylbenzoic acid

Chemical Property:

• Vapor Pressure: 8.08E-05mmHg at 25°C
• Boiling Point: 327.6°C at 760 mmHg
• Flash Point: 151.9°C
• PSA: 54.37000
• Density: 1.426g/cm³
• LogP: 1.33640
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Fluoro-2-formylbenzoic acid 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-formylbenzoic acid

There total 4 articles about 5-Fluoro-2-formylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.2%

5-fluoro-2-(hydroxymethyl)benzoic acid (1341091-61-9) → 5-fluoro-2-formylbenzoic acid (920481-01-2)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

2-Bromo-5-fluorobenzoic acid (394-28-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-fluoro-2-formylbenzoic acid (920481-01-2)

Guidance literature:

2-Bromo-5-fluorobenzoic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1039/c6md00179c

Reference yield:

6-fluoroisobenzofuran-1(3H)-one (23932-84-5) → 5-fluoro-2-formylbenzoic acid (920481-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / methanol / 1.5 h / Reflux

1.2: pH 3 - 4

2.1: manganese(IV) oxide / tetrahydrofuran / 16 h / 20 °C

With manganese(IV) oxide; water; potassium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

methyl 2-(bromomethyl)-5-fluorobenzoate

6-fluoroisobenzofuran-1(3H)-one

5-fluoro-2-(hydroxymethyl)benzoic acid

2-Bromo-5-fluorobenzoic acid

Downstream raw materials:

methyl 5-fluoro-2-formylbenzoate

2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

7-Fluor-1(2H)-phthalazinon

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