2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

Base Information

Chemical Name:2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid
CAS No.:1352835-21-2
Molecular Formula:C₃₀H₂₇FN₄O₅
Molecular Weight:542.567
Hs Code.:

Synonyms:2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

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Chemical Property of 2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

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Technology Process of 2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

There total 16 articles about 2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920481-01-2
5-fluoro-2-formylbenzoic acid

: 1352835-11-0
4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indole-1-carboxamide

: 1352835-21-2
2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,1-dichloroethane; at 20 ℃; for 16h;

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 1352835-21-2
2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2.1: tetrahydrofuran / 16 h / 125 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 4.5 h / 20 °C

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

4.3: 4.5 h / 125 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C

5.2: pH 4 - 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1.5 h / 20 °C

7.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1.5 h / 20 °C

8.1: acetic acid; sodium tris(acetoxy)borohydride / 1,1-dichloroethane; tetrahydrofuran / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,1-dichloroethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352835-21-2
2-((3-(1-carbamoyl-7-(2-methoxyethoxy)-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylamino)methyl)-5-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 4.5 h / 90 °C

4.1: tetrahydrofuran / 16 h / 125 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 4.5 h / 20 °C

6.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

6.2: pH 10

6.3: 4.5 h / 125 °C

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1.5 h / 20 °C

7.2: pH 4 - 5

8.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1.5 h / 20 °C

9.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 1.5 h / 20 °C

10.1: acetic acid; sodium tris(acetoxy)borohydride / 1,1-dichloroethane; tetrahydrofuran / 16 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide monohydrate; ammonium acetate; water; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide; toluene;