2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane

Base Information

Chemical Name:2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane
CAS No.:135267-12-8
Molecular Formula:C15H18F2O3
Molecular Weight:284.303
Hs Code.:
DSSTox Substance ID:DTXSID501141939
Mol file:135267-12-8.mol

Synonyms:135267-12-8;2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane;2-[(1r)-1-[(2r)-2-(2,4-difluorophenyl)oxiranyl]ethoxy]tetrahydro-2h-pyran;SCHEMBL2568833;DTXSID501141939;2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran;A854412;2-[(1R)-1-[(2R)-2-(2,4-Difluorophenyl)-2-oxiranyl]ethoxy]tetrahydro-2H-pyran

Suppliers and Price of 2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:284.12240076
Heavy Atom Count:20
Complexity:341

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1(CO1)C2=C(C=C(C=C2)F)F)OC3CCCCO3
Isomeric SMILES:C[C@H]([C@]1(CO1)C2=C(C=C(C=C2)F)F)OC3CCCCO3

Technology Process of 2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane

There total 8 articles about 2-[(1R)-1-[(2R)-2-(2,4-difluorophenyl)oxiran-2-yl]ethoxy]oxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 1774-47-6
trimethylsulfoxonium iodide

: 127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0
(2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 135267-12-8
2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 1774-47-6
trimethylsulfoxonium iodide

: 127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0
(2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 135267-12-8
2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran

: (2R,3S)-3-(2',4'-difluorophenyl)-3,4-epoxy-2-butyl-[3,4,5,6-tetrahydro-2H-pyran-2-yl]ether

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 55 ℃;
DOI:10.1016/0040-4039(95)02234-1

Reference yield:

: 148505-34-4
Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester

: 135267-12-8
2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

2: PPTS / Ambient temperature

3: 60percent NaH / dimethylsulfoxide; tetrahydrofuran / 55 °C

With pyridinium p-toluenesulfonate; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/0040-4039(95)02234-1