(2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Base Information

Chemical Name:(2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS No.:135133-23-2
Molecular Formula:C₁₇H₂₁F₂N₃O₃
Molecular Weight:353.369
Hs Code.:

Synonyms:(3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Suppliers and Price of (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol3-THPEther
5mg
$ 310.00

Total 5 raw suppliers

Chemical Property of (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Chemical Property:

Boiling Point:533.9±60.0 °C(Predicted)
PKA:11.61±0.29(Predicted)
Density:1.35±0.1 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol3-THPEther ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 3-THP Ether is an impurity of efinaconazole (E435070).

Technology Process of (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

There total 11 articles about (2R,3R)-2-(2,4-Difluorophenyl)-3-((tetrahydro-2H-pyran-2-yl)oxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 288-88-0
1,2,4-Triazole

: 135267-12-8
2-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethoxy)tetrahydro-2H-pyran

: 135133-23-2
(3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Guidance literature:: With potassium carbonate; at 100 ℃; for 6h;
DOI:10.5012/bkcs.2010.31.11.3467

Reference yield: 88.0%

: 288-88-0
1,2,4-Triazole

: 212890-35-2
2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane

: (3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

: C₁₇H₂₁F₂N₃O₃

: 135133-23-2
(3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Guidance literature:: With sodium t-butanolate; In N,N-dimethyl-formamide; at 80 - 90 ℃;
DOI:10.1021/op900065c

Reference yield:

: 135270-08-5
4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

: 135133-23-2
(3R)-2-(2,4-difluorophenyl)-3-(tetrahydropyran-2-yloxy)-1-[1,2,4]triazol-1-yl-butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 20 °C

2: dichloromethane / 70 °C

3: potassium carbonate / 6 h / 100 °C

With potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.5012/bkcs.2010.31.11.3467