1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Base Information

• Chemical Name: 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone
• CAS No.: 444663-79-0
• Molecular Formula: C₁₅H₁₁BrCl₂N₂O₂
• Molecular Weight: 402.075
• Mol file: 444663-79-0.mol

Synonyms:1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property of 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

There total 5 articles about 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-78-9) → 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-79-0)

Guidance literature:

With trifluoroacetic acid; Heating;

DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

2,6-dibromo-4-methoxytoluene (14542-71-3) → 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-79-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NBS; Bz₂O₂

2: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

3: TFA / Heating

With N-Bromosuccinimide; copper(l) iodide; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In N,N-dimethyl-formamide; 4: Ullmann coupling;

DOI:10.1016/S0960-894X(02)00752-7

Reference yield:

1,3-dibromo-2-(bromomethyl)-5-methoxybenzene (130445-13-5) → 1-(2,6-dichlorophenyl)-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone (444663-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: CuI; K₂CO₃ / dimethylformamide / 0.25 h / 150 °C

2: TFA / Heating

With copper(l) iodide; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide; 3: Ullmann coupling;

DOI:10.1016/S0960-894X(02)00752-7

upstream raw materials:

1-(2,6-dichlorophenyl)-3-(4-methoxyphenyl)methyl-5-bromo-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

2,6-dibromo-4-methoxytoluene

1,3-dibromo-2-(bromomethyl)-5-methoxybenzene

(2,6-dibromo-4-methoxy-benzyl)-(4-methoxy-benzyl)-amine

Downstream raw materials:

1-(2,6-dichlorophenyl)-5-(2-chloro-4-fluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-methoxy-3,4-dihydro-2(1H)-quinazolinone

4-[1-(2,6-dichloro-phenyl)-5-(2,4-difluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

trifluoro-methanesulfonic acid 5-(2-chloro-4-fluoro-phenyl)-1-(2,6-dichloro-phenyl)-2-oxo-1,2,3,4-tetrahydro-quinazolin-7-yl ester