1-Boc-3-(hydroxyMethyl)-3-Methylazetidine

Base Information

• Chemical Name: 1-Boc-3-(hydroxyMethyl)-3-Methylazetidine
• CAS No.: 1363382-91-5
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26276
• Hs Code.: 2933990090
• Mol file: 1363382-91-5.mol

Synonyms:1-Boc-3-(hydroxyMethyl)-3-Methylazetidine;tert-Butyl 3-(hydroxyMethyl)-3-Methylazetidine-1-carboxylate;3-(Hydroxymethyl)-3-methylazetidine,N-BOCprotected

Chemical Property of 1-Boc-3-(hydroxyMethyl)-3-Methylazetidine

Chemical Property:

• Boiling Point: 274.5±13.0 °C(Predicted)
• PKA: 14.82±0.10(Predicted)
• PSA: 49.77000
• Density: 1.080±0.06 g/cm3(Predicted)
• LogP: 1.17360
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl3-(hydroxymethyl)-3-methylazetidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-(hydroxyMethyl)-3-Methylazetidine

There total 3 articles about 1-Boc-3-(hydroxyMethyl)-3-Methylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (898228-37-0) → 3-hydroxymethyl-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (1363382-91-5)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

1-[(tert-butoxy)carbonyl]-3-methylazetidine-3-carboxylic acid (887591-62-0) → 3-hydroxymethyl-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (1363382-91-5)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (610791-05-4) → 3-hydroxymethyl-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (1363382-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

1.2: 72 h / 20 °C

2.1: lithium borohydride / tetrahydrofuran / 19 h / 20 °C / Inert atmosphere

2.2: 50 h / 20 °C

With lithium borohydride; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

3-methyl-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

1-[(tert-butoxy)carbonyl]-3-methylazetidine-3-carboxylic acid

azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Downstream raw materials:

3-hydroxymethyl-3-methyl-azetidine hydrochloride