methyl 4-acetoxy-8-bromo-5-methoxy-naphthalene-2-carboxylate

Base Information

• Chemical Name: methyl 4-acetoxy-8-bromo-5-methoxy-naphthalene-2-carboxylate
• CAS No.: 115061-22-8
• Molecular Formula: C₁₅H₁₃BrO₅
• Molecular Weight: 353.169
• Mol file: 115061-22-8.mol

Synonyms:2-Naphthalenecarboxylic acid, 4-(acetyloxy)-8-broMo-5-Methoxy-, Methyl ester

Chemical Property of methyl 4-acetoxy-8-bromo-5-methoxy-naphthalene-2-carboxylate

Chemical Property:

• Vapor Pressure: 3.74E-09mmHg at 25°C
• Boiling Point: 474°C at 760 mmHg
• Flash Point: 240.5°C
• PSA: 61.83000
• Density: 1.476g/cm³
• LogP: 3.32280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-acetoxy-8-bromo-5-methoxy-naphthalene-2-carboxylate

There total 3 articles about methyl 4-acetoxy-8-bromo-5-methoxy-naphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic anhydride (108-24-7) + 2-[1-(2-Bromo-5-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester (115061-21-7) → methyl 4-acetoxy-8-bromo-5-methoxynaphthalene-2-carboxylate (115061-22-8)

Guidance literature:

With potassium acetate; for 0.166667h; Heating;

Reference yield:

2-bromo-5-methoxy-benzaldehyde (7507-86-0) → methyl 4-acetoxy-8-bromo-5-methoxynaphthalene-2-carboxylate (115061-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / benzene / 48 h / Heating

2: 98 percent / 90percent trifluoroacetic acid / 0.17 h / Ambient temperature

3: 98 percent / potassium acetate / 0.17 h / Heating

With potassium acetate; trifluoroacetic acid; In benzene;

Reference yield:

2-[1-(2-Bromo-5-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester (115046-51-0) → methyl 4-acetoxy-8-bromo-5-methoxynaphthalene-2-carboxylate (115061-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 90percent trifluoroacetic acid / 0.17 h / Ambient temperature

2: 98 percent / potassium acetate / 0.17 h / Heating

With potassium acetate; trifluoroacetic acid;

upstream raw materials:

acetic anhydride

2-[1-(2-Bromo-5-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester

2-bromo-5-methoxy-benzaldehyde

2-[1-(2-Bromo-5-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 4-tert-butyl ester 1-methyl ester

Downstream raw materials:

nepodin

4-acetoxy-5-methoxy-[2]naphthoic acid methyl ester