Amino-PEG8-azide

Base Information

• Chemical Name: Amino-PEG8-azide
• CAS No.: 1333154-77-0
• Molecular Formula: C16H34N4O7
• Molecular Weight: 394.46376
• Hs Code.: 2942000090
• Mol file: 1333154-77-0.mol

Synonyms:Amino-PEG8-azide;Azido-PEG7-amine

Chemical Property of Amino-PEG8-azide

Chemical Property:

• PSA: 140.38000
• LogP: 0.52466
• Storage Temp.: -20°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Azido-PEG7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Azido-dPEG7-amine is a heterobifunctional PEGylated linker. It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors.
• Uses: Azido-PEG7-amine is used in methods for detecting assay interferences and increasing dynamic range.

Technology Process of Amino-PEG8-azide

There total 11 articles about Amino-PEG8-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C24H36N4O9 (1422541-03-4) → α-amino,ω-azido,α,ω-dideoxy-octaethyleneglycol (1333154-77-0)

Guidance literature:

With hydrazine; In ethanol; at 60 ℃; for 3h;

DOI:10.1039/c2ob26968f

Reference yield: 89.1%

α,ω-diazido,α,ω-dideoxy-octaethyleneglycol (225523-86-4,82055-94-5) → α-amino,ω-azido,α,ω-dideoxy-octaethyleneglycol (1333154-77-0)

Guidance literature:

α,ω-diazido,α,ω-dideoxy-octaethyleneglycol; With hydrogenchloride; water; triphenylphosphine; In toluene; at 20 ℃; Inert atmosphere;

With sodium hydroxide; Inert atmosphere;

DOI:10.1002/cmdc.201200493

Reference yield:

octaethylene glycol (5117-19-1) → α-amino,ω-azido,α,ω-dideoxy-octaethyleneglycol (1333154-77-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 4 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 15 h / 65 °C

3: hydrogenchloride; triphenylphosphine / water; diethyl ether / 20 °C

With hydrogenchloride; sodium azide; triethylamine; triphenylphosphine; In diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; 3: |Staudinger Azide Reduction;

DOI:10.1039/c2ob26968f

upstream raw materials:

octaethylene glycol

23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl methanesulfonate

α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene)

3,6,9,12,15,18,21-heptaoxatricosane-1,23-diyl dimethanesulfonate

Downstream raw materials:

α-(2-azidoethyl)-ω-(2-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido)ethoxy)hexa(oxyethylene)

tert-butyl (23-azido-3,6,9,12,15,18,21-heptaoxatricosyl)carbamate

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