tert-Butyl 2-bromo-4-fluorobenzoate

Base Information

• Chemical Name: tert-Butyl 2-bromo-4-fluorobenzoate
• CAS No.: 951884-50-7
• Molecular Formula: C11H12BrFO2
• Molecular Weight: 275.117
• Hs Code.: 2916399090
• Mol file: 951884-50-7.mol

Synonyms:Benzoic acid, 2-broMo-4-fluoro-, 1,1-diMethylethyl ester

Chemical Property of tert-Butyl 2-bromo-4-fluorobenzoate

Chemical Property:

• Vapor Pressure: 0.00366mmHg at 25°C
• Boiling Point: 281°C at 760 mmHg
• Flash Point: 123.7°C
• PSA: 26.30000
• Density: 1.394g/cm³
• LogP: 3.54350
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥95% ^*data from raw suppliers

tert-Butyl2-Bromo-4-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 2-bromo-4-fluorobenzoate

There total 3 articles about tert-Butyl 2-bromo-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-Butoxycarbonylpivalat (39982-01-9) + 2-bromo-4-fluorobenzoic acid (1006-41-3) → 2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7)

Guidance literature:

With dmap; In tert-butyl alcohol; at 0 - 90 ℃; for 2h; Inert atmosphere;

Reference yield: 51.9%

2-bromo-4-fluorobenzoic acid (1006-41-3) → 2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide;

Reference yield: 42.0%

2-bromo-4-fluorobenzoic acid (1006-41-3) + tert-butyl alcohol (75-65-0) → 2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7)

Guidance literature:

2-bromo-4-fluorobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;

tert-butyl alcohol; With pyridine; In dichloromethane; at 20 ℃; for 72h;

upstream raw materials:

2-bromo-4-fluorobenzoic acid

tert-butyl alcohol

tert-Butoxycarbonylpivalat

Downstream raw materials:

2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-5-carboxylic acid

4-[(2-fluoro-4-iodophenyl)amino]-1H-indazole-5-carboxylic acid

4-(2-fluoro-4-trimethylsilanylphenylamino)indazole-1,5-dicarboxylic acid di-tert-butyl ester

Refernces

• 1、 -. "BENZIMIDAZOLE-INDOLE INHIBITORS OF MNK1 AND MNK2". Paragraph 0243; 0331-0332. . Retrieved 2019/05/07.
• 2、 -. "BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS". Page/Page column 62. . Retrieved 2010/04/03.