2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

Base Information

• Chemical Name: 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester
• CAS No.: 1203662-35-4
• Molecular Formula: C₁₂H₁₂BrFO₃
• Molecular Weight: 303.128
• Mol file: 1203662-35-4.mol

Synonyms:2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

Chemical Property of 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

More than 98% ^*data from raw suppliers

tert-butyl2-bromo-4-fluoro-3-formylbenzoate 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester

There total 4 articles about 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester (1203662-35-4)

Guidance literature:

2-bromo-4-fluorobenzoic acid tert-butyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃; for 1.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; for 0.166667h; regiospecific reaction;

DOI:10.1021/jm2017094

Reference yield: 48.0%

2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7) → 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester (1203662-35-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

2-bromo-4-fluorobenzoic acid tert-butyl ester (951884-50-7) + formic acid ethyl ester (109-94-4) → 2-bromo-4-fluoro-3-formylbenzoic acid tert-butyl ester (1203662-35-4)

Guidance literature:

With lithium diisopropyl amide;

upstream raw materials:

2-bromo-4-fluorobenzoic acid tert-butyl ester

N,N-dimethyl-formamide

2-bromo-4-fluorobenzoic acid

formic acid ethyl ester

Downstream raw materials:

4-benzylsulfanyl-2-bromo-3-formyl-benzoic acid tert-butyl ester

4-bromo-1H-indazole-5-carboxylic acid tert-butyl ester

4-[(4-bromo-2-fluorophenyl)amino]-1H-indazole-5-carboxylic acid (2-hydroxyethoxy)amide

4-[(2-fluoro-4-iodophenyl)amino]-1H-indazole-5-carboxylic acid cyclopropylmethoxyamide

Refernces

• 1、 -. "BENZIMIDAZOLE-INDOLE INHIBITORS OF MNK1 AND MNK2". . . Retrieved 2019/05/07.
• 2、 -. "BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS". Page/Page column 62-63. . Retrieved 2010/04/03.