5-bromo-8-(trifluoromethyl)quinoline

Base Information

• Chemical Name: 5-bromo-8-(trifluoromethyl)quinoline
• CAS No.: 1239460-75-3
• Molecular Formula: C10H5BrF3N
• Molecular Weight: 276.056
• Mol file: 1239460-75-3.mol

Synonyms:5-bromo-8-(trifluoromethyl)quinoline

Chemical Property of 5-bromo-8-(trifluoromethyl)quinoline

Chemical Property:

• PSA: 12.89000
• LogP: 4.01610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-8-(trifluoromethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-8-(trifluoromethyl)quinoline

There total 2 articles about 5-bromo-8-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

Togni's reagent II (887144-94-7) + 5-bromoquinoline (4964-71-0) → 5-bromo-8-(trifluoromethyl)quinoline (1239460-75-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 75 ℃; for 6h; Mechanism; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.151538

Reference yield: 48.0%

5-bromo-2-trifluoromethylphenylamine (703-91-3) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5-bromo-8-(trifluoromethyl)quinoline (1239460-75-3)

Guidance literature:

5-bromo-2-trifluoromethylphenylamine; glycerol; With sulfuric acid; iron(II) sulfate; at 120 ℃; for 4h;

With water; sodium hydroxide; In ethanol; ethyl acetate; nitrobenzene; at 20 ℃; pH=13;

upstream raw materials:

5-bromo-2-trifluoromethylphenylamine

glycerol

Togni's reagent II

5-bromoquinoline

Refernces

• 1、 Bowers, Simeon,Truong, Anh P.,Jeffrey Neitz,Hom, Roy K.,Sealy, Jennifer M.,Probst, Gary D.,Quincy, David,Peterson, Brian,Chan, Wayman,Galemmo Jr., Robert A.,Konradi, Andrei W.,Sham, Hing L.,Tóth, Gergely,Pan, Hu,Lin, May,Yao, Nanhua,Artis, Dean R.,Zhang, Heather,Chen, Linda,Dryer, Mark,Samant, Bhushan,Zmolek, Wes,Wong, Karina,Lorentzen, Colin,Goldbach, Erich,Tonn, George,Quinn, Kevin P.,Sauer, John-Michael,Wright, Sarah,Powell, Kyle,Ruslim, Lany,Ren, Zhao,Bard, Frédérique,Yednock, Ted A.,Griswold-Prenner, Irene. "Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration". scheme or table. p. 5521 - 5527. Retrieved 2011/10/09.