5-Bromo-2-(trifluoromethyl)aniline

Base Information

• Chemical Name: 5-Bromo-2-(trifluoromethyl)aniline
• CAS No.: 703-91-3
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.023
• Hs Code.: 2921420090
• Mol file: 703-91-3.mol

Synonyms:o-Toluidine,5-bromo-a,a,a-trifluoro- (7CI,8CI);5-Bromo-2-trifluoromethylaniline;

Chemical Property of 5-Bromo-2-(trifluoromethyl)aniline

Chemical Property:

• Boiling Point: 254.8 °C at 760 mmHg
• PKA: 0.39±0.10(Predicted)
• Flash Point: 107.9 °C
• PSA: 26.02000
• Density: 1.697 g/cm³
• LogP: 3.63130
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-(Trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-(trifluoromethyl)aniline

There total 5 articles about 5-Bromo-2-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromo-2-nitro-1-(trifluoromethyl)benzene (251115-21-6) → 5-bromo-2-trifluoromethylphenylamine (703-91-3)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; at 80 ℃; for 1h;

Reference yield: 27.0%

Togni's reagent II (887144-94-7) + m-Bromoaniline (591-19-5) → 5-bromo-2-trifluoromethylphenylamine (703-91-3) + 3-bromo-2-(trifluoromethyl)aniline (244246-71-7)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Irradiation;

Reference yield: 23.0%

Togni's reagent II (887144-94-7) + m-Bromoaniline (591-19-5) → 5-bromo-2-trifluoromethylphenylamine (703-91-3) + 3-bromo-4-(trifluoromethyl)aniline (172215-91-7) + 3-bromo-2-(trifluoromethyl)aniline (244246-71-7)

Guidance literature:

With potassium carbonate; nickel(II) hydroxide; In dimethyl sulfoxide; at 35 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01216

upstream raw materials:

4-bromo-2-nitro-1-(trifluoromethyl)benzene

Togni's reagent II

m-Bromoaniline

Downstream raw materials:

5-bromo-8-(trifluoromethyl)quinoline

Refernces

• 1、 -. "Preparation method of trifluoromethylamine". Paragraph 0212-0216; 0220-0222; 0226-0228. . Retrieved 2018/09/28.
• 2、 -. "A for the preparation of ortho-trifluoromethyl-aniline or its derivatives (by machine translation)". Paragraph 0041-0042. . Retrieved 2016/10/24.