Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate

Base Information

• Chemical Name: Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate
• CAS No.: 119740-95-3
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.265
• Mol file: 119740-95-3.mol

Synonyms:Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate;tert-butyl 2-(methoxycarbonyl)ethylmethylcarbamate

Chemical Property of Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate

Chemical Property:

• Boiling Point: 275.6±19.0 °C(Predicted)
• PKA: -1.52±0.70(Predicted)
• PSA: 55.84000
• Density: 1.045±0.06 g/cm3(Predicted)
• LogP: 1.41640
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-((tert-butoxycarbonyl)(methyl)amino)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate

There total 8 articles about Methyl 3-((tert-butoxycarbonyl)(methyl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 3-(methylamino)propanoate (24549-12-0) + di-tert-butyl dicarbonate (24424-99-5) → methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate (119740-95-3)

Guidance literature:

In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85078-X

Reference yield: 93.0%

methyl 3-tert-butoxycarbonylaminopropionate (42116-55-2) + methyl iodide (74-88-4) → methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate (119740-95-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2005.08.096

Reference yield: 92.0%

N-t-butoxycarbonyl-N-methyl-β-alanine (124072-61-3) + methyl iodide (74-88-4) → methyl 3-(N-tert-butoxycarbonyl-N-methyl)-aminopropionate (119740-95-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

upstream raw materials:

methyl 3-(methylamino)propanoate

di-tert-butyl dicarbonate

methanol

N-t-butoxycarbonyl-N-methyl-β-alanine

Downstream raw materials:

methyl 3-(N-methylamino)propionate hydrochloride

tert-butyl (3-hydroxypropyl)methylcarbamate

1-methyl-dihydro-pyrimidine-2,4-dione

ethyl 5-[(tert-butoxycarbonyl)(methyl)amino]-3-[(4-methoxyphenyl)amino]pent-2-enoate

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