2-amino-N-methyl-2-phenylacetamide

Base Information

• Chemical Name: 2-amino-N-methyl-2-phenylacetamide
• CAS No.: 93782-07-1
• Molecular Formula: C11H12BrN3O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• Mol file: 93782-07-1.mol

Synonyms:2-amino-N-methyl-2-phenylacetamide;6-Bromo-1-cyclopentyl-1H,2H,3H-imidazo[4,5-b]pyridin-2-one

Chemical Property of 2-amino-N-methyl-2-phenylacetamide

Chemical Property:

• PSA: 50.68000
• LogP: 2.60220

Purity/Quality:

95-99% ^*data from raw suppliers

2-Amino-N-methyl-2-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-N-methyl-2-phenylacetamide

There total 13 articles about 2-amino-N-methyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

DL-2-phenylglycine methyl ester hydrochloride (15028-40-7,13226-98-7) + methylamine (74-89-5) → α-amino-2-phenyl-N-methylacetamide (93782-07-1)

Guidance literature:

In water; at 20 - 22 ℃; for 1.5h;

Reference yield: 94.0%

C16H24N2O4 → α-amino-2-phenyl-N-methylacetamide (93782-07-1)

Guidance literature:

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 20h;

DOI:10.1016/j.tet.2020.131476

Reference yield: 64.0%

(R)-2,2,3-trimethyl-5-phenylimidazolidin-4-one → (R)-2-amino-N-methyl-2-phenylacetamide (93782-07-1,95523-35-6,129213-83-8,97549-10-5)

Guidance literature:

With hydrogenchloride; acetic acid; In water; toluene; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1039/c7cc01561e

upstream raw materials:

2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-N-methyl-2-phenyl-acetamide

ethyl 2-phenyl-2-aminoacetate

methylamine

DL-2-phenylglycine methyl ester hydrochloride

Downstream raw materials:

(R)-(+)-1-methyl-4-phenyl-2-(pyrid-2-yl)imidazoline

(R)-N¹-methyl-1-phenylethane-1,2-diamine

(2S,5R)-2-(tert-Butyl)-3-methyl-5-phenylimidazoldin-4-on

Refernces

• 1、 Uemura, Takahito,Saito, Yusuke,Sonoda, Motohiro,Tanimori, Shinji. "A Concise Enantiodivergent Synthesis of Equol". . p. 693 - 696. Retrieved 2020/12/23.
• 2、 Wagner, Christian,Kotthaus, Andreas F.,Kirsch, Stefan F.. "The asymmetric reduction of imidazolinones with trichlorosilane". . p. 4513 - 4516. Retrieved 2017/04/26.