1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile
CAS No.:1096141-50-2
Molecular Formula:C₂₂H₂₄N₂O₂
Molecular Weight:348.445
Hs Code.:

Synonyms:1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Suppliers and Price of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

There total 8 articles about 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-22-5
Isopropenyl acetate

: 1096141-54-6
1-(3-(benzyloxy)propyl)-5-bromoindoline-7-carbonitrile

: 1067-52-3
tributyltin methoxide

: 1096141-50-2
1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Guidance literature:: Isopropenyl acetate; 1-(3-(benzyloxy)propyl)-5-bromoindoline-7-carbonitrile; tributyltin methoxide; In toluene; at 20 ℃; for 1h; Inert atmosphere of nitrogen;

With DavePhos; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 75 - 85 ℃; for 1.5h;

Reference yield:

: 1374461-77-4
1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile

: 1096141-50-2
1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Guidance literature:: With hydrogenchloride; iron(III) chloride; water; iron; at 60 - 90 ℃; for 2.5h;

Reference yield:

: 100-39-0
benzyl bromide

: 1096141-50-2
1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 22 h / Reflux

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 25.5 h / 130 °C

3.1: trichlorophosphate / 1 h / 0 - 5 °C

3.2: 21.17 h / 20 °C / Cooling

3.3: 4 h / 35 °C

4.1: bromine; acetic acid / 0.67 h / 20 °C

5.1: N,N-dimethyl-formamide / 150 °C / Inert atmosphere

5.2: 0.25 h / 70 °C

6.1: ammonium acetate / 4.5 h / 125 °C

6.2: 0.5 h / 20 °C

7.1: hydrogenchloride; water; iron; iron(III) chloride / 2.5 h / 60 - 90 °C

With hydrogenchloride; iron(III) chloride; ammonium acetate; water; bromine; iron; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; trichlorophosphate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; N,N-dimethyl-formamide;