rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide

Base Information

Chemical Name:rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide
CAS No.:178677-89-9
Molecular Formula:C₁₅H₂₁NO₂
Molecular Weight:247.337
Hs Code.:
Mol file:178677-89-9.mol

Synonyms:rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide;N-[2-(2,3-Dihydro-6-Methoxy-1H-inden-1-yl)ethyl]propanaMide

Suppliers and Price of rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide

Chemical Property:

PSA：41.82000
LogP:3.48160
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Intermediate in the production of Ramelteon.

Technology Process of rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide

There total 4 articles about rac-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 79-03-8
propionyl chloride

: 108048-37-9
2,3-dihydro-6-methoxy-1H-inden-1-ethanamine

: 178677-89-9
(+/-)-N-[2-(6-methoxyindan-1-yl)ethyl]propanamide

Guidance literature:

Reference yield:

: 13623-25-1
6-methoxy-2,3-dihydro-1H-inden-1-one

: 178677-89-9
(+/-)-N-[2-(6-methoxyindan-1-yl)ethyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 20 °C

1.2: tetrahydrofuran / 20 °C

2.1: H₂; ethanolic NH₃ / Raney-nickel / 40 °C / 3600.36 Torr

3.1: Et₃N / tetrahydrofuran

With ammonia; hydrogen; sodium hydride; triethylamine; nickel; In tetrahydrofuran; 1.2: Horner-Emmons reaction;
DOI:10.1021/jm0201159

Reference yield:

: 187871-98-3
(E)-(2,3-dihydro-6-methoxy-1H-inden-1-ylidene)acetonitrile

: 178677-89-9
(+/-)-N-[2-(6-methoxyindan-1-yl)ethyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂; ethanolic NH₃ / Raney-nickel / 40 °C / 3600.36 Torr

2: Et₃N / tetrahydrofuran

With ammonia; hydrogen; triethylamine; nickel; In tetrahydrofuran;
DOI:10.1021/jm0201159