tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate
CAS No.:1001397-71-2
Molecular Formula:C₂₄H₂₉IN₂O₃
Molecular Weight:520.41
Hs Code.:
Mol file:1001397-71-2.mol

Synonyms:tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(1-(4-iodophenyl)indolin-4-yloxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1001397-70-1
1,1-dimethylethyl 4-{[1-(4-iodophenyl)-1H-indol-4-yl]oxy}-1-piperidine carboxylate

: 1001397-71-2
1,1-dimethylethyl 4-{[1-(4-iodophenyl)-2,3-dihydro-1H-indol-4-yl]oxy}-1-piperidinecarboxylate

Guidance literature:: With sodium cyanoborohydride; In acetic acid; at 20 ℃; for 15h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1001397-71-2
1,1-dimethylethyl 4-{[1-(4-iodophenyl)-2,3-dihydro-1H-indol-4-yl]oxy}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 5 - 20 °C / Inert atmosphere

2: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

3: sodium cyanoborohydride; acetic acid / 20 °C

With potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; (1R,2R)-1,2-diaminocyclohexane; sodium cyanoborohydride; acetic acid; triphenylphosphine; In tetrahydrofuran; 2: |Buchwald Indole Synthesis;
DOI:10.1021/jm301404a

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 1001397-71-2
1,1-dimethylethyl 4-{[1-(4-iodophenyl)-2,3-dihydro-1H-indol-4-yl]oxy}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 5 - 20 °C / Inert atmosphere

2: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

3: sodium cyanoborohydride; acetic acid / 20 °C

With potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; (1R,2R)-1,2-diaminocyclohexane; sodium cyanoborohydride; acetic acid; triphenylphosphine; In tetrahydrofuran; 2: |Buchwald Indole Synthesis;
DOI:10.1021/jm301404a