1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Base Information

Chemical Name:1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate
CAS No.:1001397-75-6
Molecular Formula:C₂₄H₃₀N₂O₅S
Molecular Weight:458.579
Hs Code.:

Synonyms:1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

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Chemical Property of 1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

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Technology Process of 1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

There total 5 articles about 1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1001397-75-6
1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:

Reference yield: 54.0%

: 1001397-72-3
1,1-dimethylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

: 108-23-6
isopropyl chloroformate

: 1001397-75-6
1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: 1,1-dimethylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

isopropyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 8h;
DOI:10.1021/jm301404a

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1001397-75-6
1-methylethyl 4-({1-[4-(methylsulfonyl)phenyl]-2,3-dihydro-1H-indol-4-yl}oxy)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 5 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

3.1: copper(l) iodide; L-proline; sodium hydroxide / dimethyl sulfoxide / 18 h / 110 °C / Sealed tube

4.1: sodium cyanoborohydride; acetic acid / 36 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

5.2: 8 h / 20 °C

With potassium phosphate; copper(l) iodide; di-isopropyl azodicarboxylate; (1R,2R)-1,2-diaminocyclohexane; sodium cyanoborohydride; acetic acid; triphenylphosphine; trifluoroacetic acid; L-proline; sodium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2.1: |Buchwald Indole Synthesis;
DOI:10.1021/jm301404a