2-Methylpropane-2-sulfinic acid methyl ester

Base Information

• Chemical Name: 2-Methylpropane-2-sulfinic acid methyl ester
• CAS No.: 52056-71-0
• Molecular Formula: C₅H₁₂O₂S
• Molecular Weight: 136.215
• Mol file: 52056-71-0.mol

Synonyms:2-Methyl-2-propanesulfinic acid methyl ester;2-Methylpropane-2-sulfinic acid methyl ester;methyl 2-methylpropane-2-sulfinate

Chemical Property of 2-Methylpropane-2-sulfinic acid methyl ester

Chemical Property:

• Boiling Point: 179.2±23.0 °C(Predicted)
• PSA: 45.51000
• Density: 1.072±0.06 g/cm3(Predicted)
• LogP: 1.96070

Purity/Quality:

99% ^*data from raw suppliers

methyl2-methylpropane-2-sulfinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylpropane-2-sulfinic acid methyl ester

There total 4 articles about 2-Methylpropane-2-sulfinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

dimethylsulfite (616-42-2) + tert-butylmagnesium chloride (677-22-5) → methyl t-butanesulfinate (52056-71-0)

Guidance literature:

With Quinine; In diethyl ether; for 13h; Heating;

DOI:10.1016/S0040-4020(01)86031-2

Reference yield: 29.0%

methanol (67-56-1) + (R)-2-methyl-N-((R)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl)propane-2-sulfinamide (1429187-78-9) → (R)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-amine hydrochloride (1429187-76-7) + methyl t-butanesulfinate (52056-71-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.333333h;

Reference yield:

dimethylsulfite (616-42-2) + tertiary butyl chloride (507-20-0) → methyl t-butanesulfinate (52056-71-0)

Guidance literature:

Multistep reaction; (i) Mg, Et₂O, (ii) /BRN= 1700256/;

DOI:10.1055/s-1974-23258

upstream raw materials:

dimethylsulfite

tertiary butyl chloride

tert-butylmagnesium chloride

tert-butylsulfinyl chloride

Downstream raw materials:

(tert-butylsulfinyl)benzene