N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Base Information

Chemical Name:N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide
CAS No.:272788-07-5
Molecular Formula:C16H23NO3
Molecular Weight:277.364
Hs Code.:
DSSTox Substance ID:DTXSID00573582
Mol file:272788-07-5.mol

Synonyms:272788-07-5;N-FORMYL-1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL)CYCLOHEXANOL;N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide;SCHEMBL12187989;DTXSID00573582

Suppliers and Price of N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Formyl-1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol
100mg
$ 1230.00

Medical Isotopes, Inc.
N-Formyl-1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol
10 mg
$ 825.00

American Custom Chemicals Corporation
N-FORMYL-1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL)CYCLOHEXANOL 95.00%
100MG
$ 1871.10

American Custom Chemicals Corporation
N-FORMYL-1-(2-AMINO-1-(4-METHOXYPHENYL)ETHYL)CYCLOHEXANOL 95.00%
10MG
$ 315.00

Total 5 raw suppliers

Chemical Property of N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Chemical Property:

PSA：62.05000
LogP:3.06030
Solubility.:Chloroform, Ethyl Acetate, Methanol
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:277.16779360
Heavy Atom Count:20
Complexity:294

Purity/Quality:

NLT 98% ^*data from raw suppliers

N-Formyl-1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(CNC=O)C2(CCCCC2)O
Uses An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine.

Technology Process of N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

There total 4 articles about N-[2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 64-18-6
formic acid

: 93413-77-5,272788-06-4,273720-73-3,149289-31-6
N,N-didesmethylvenlafaxine

: 272788-07-5
N-[2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Guidance literature:: In toluene; for 5h; Reflux;
DOI:10.1080/00397910903162767

Reference yield:

: 93413-76-4,131801-69-9
1-[cyano(4-methoxyphenyl)methyl]cyclohexanol

: 272788-07-5
N-[2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Guidance literature:: Multi-step reaction with 2 steps

1: cobalt(II) chloride; sodium tetrahydroborate / methanol / 2 h / 20 - 35 °C

2: toluene / 4 h / Reflux

With sodium tetrahydroborate; cobalt(II) chloride; In methanol; toluene;

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 272788-07-5
N-[2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl]formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - -65 °C

1.2: 2 h / -78 - -65 °C

2.1: cobalt(II) chloride; sodium tetrahydroborate / methanol / 2 h / 20 - 35 °C

3.1: toluene / 4 h / Reflux

With sodium tetrahydroborate; cobalt(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;