N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide

Base Information

Chemical Name:N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide
CAS No.:240815-51-4
Molecular Formula:C₉H₆Cl₂N₄O
Molecular Weight:257.079
Hs Code.:
DSSTox Substance ID:DTXSID40573763
Nikkaji Number:J1.528.943K
Wikidata:Q82462583
Mol file:240815-51-4.mol

Synonyms:240815-51-4;N-(2,6-DICHLOROPYRIDIN-3-YL)-1H-IMIDAZOLE-5-CARBOXAMIDE;SCHEMBL4039892;DTXSID40573763;AB43848

Suppliers and Price of N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N-(2,6-DICHLOROPYRIDIN-3-YL)-1H-IMIDAZOLE-5-CARBOXAMIDE 95.00%
5MG
$ 502.44

Total 3 raw suppliers

Chemical Property of N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide

Chemical Property:

Boiling Point:409.2±45.0 °C(Predicted)
PKA:10.39±0.10(Predicted)
PSA：73.80000
Density:1.637±0.06 g/cm3(Predicted)
LogP:2.37330
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:255.9918662
Heavy Atom Count:16
Complexity:266

Purity/Quality:

98%min ^*data from raw suppliers

N-(2,6-DICHLOROPYRIDIN-3-YL)-1H-IMIDAZOLE-5-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=NC(=C1NC(=O)C2=CN=CN2)Cl)Cl

Technology Process of N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide

There total 2 articles about N-(2,6-Dichloropyridin-3-YL)-1H-imidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 62476-56-6
3-amino-2,6-dichloropyridine

: 53525-65-8
5H,10H-diimidazo[1,5-a:1,5-d]pyrazine-5,10-dione

: 240815-51-4
3H-imidazole-4-carboxylic acid (2,6-dichloro-pyridin-3-yl)-amide

Guidance literature:: 3-amino-2,6-dichloropyridine; With sodium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 1h;

5H,10H-diimidazo[1,5-a:1,5-d]pyrazine-5,10-dione; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4039(01)00698-0

Reference yield:

: 62476-56-6
3-amino-2,6-dichloropyridine

: 53525-65-8
5H,10H-diimidazo[1,5-a:1,5-d]pyrazine-5,10-dione

: 240815-51-4
N-(2,6-Dichloro-3-pyridinyl)-1H-imidazole-4-carboxamide

Guidance literature:: 3-amino-2,6-dichloropyridine; With sodium hexamethyldisilazane; In tetrahydrofuran; for 0.5h;

5H,10H-diimidazo[1,5-a:1,5-d]pyrazine-5,10-dione; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

: 240815-51-4
3H-imidazole-4-carboxylic acid (2,6-dichloro-pyridin-3-yl)-amide

: N-(2-Chloro-6-methylphenyl)-2-(4-methyl-1-piperazinyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-acetamide / Heating

2.1: phosphorus oxychloride / Heating

3.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / Heating

3.2: 98 percent / tetrahydrofuran / 0.5 h / Heating

4.1: 5 h / 120 °C

With sodium hexamethyldisilazane; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1021/jm030217e