Technology Process of 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
There total 5 articles about 2-methyl-1-(3-morpholin-4-ylpropyl)-5-phenyl-N-[3-(trifluoromethyl)phenyl]pyrrole-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methyl-1-(3-morpholinopropyl)-5-phenyl-1H-pyrrole-3-carboxylic acid;
With
thionyl chloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
3-trifluoromethylaniline;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 3-hydroxy-4-methylbenzenesulfonic acid / ethanol / 16 h / Inert atmosphere; Reflux
2: potassium hydroxide / ethanol; water / Reflux
3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
With
thionyl chloride; 3-hydroxy-4-methylbenzenesulfonic acid; potassium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
1.2: 4 h / 50 °C
2.1: potassium hydroxide / ethanol; water / Reflux
3.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
With
thionyl chloride; sodium hydride; potassium hydroxide;
In
ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
