Methyl 4-broMo-2-chloro-5-fluorobenzoate

Base Information

• Chemical Name: Methyl 4-broMo-2-chloro-5-fluorobenzoate
• CAS No.: 908248-32-8
• Molecular Formula: C8H5BrClFO2
• Molecular Weight: 267.482
• Hs Code.: 2916399090
• Mol file: 908248-32-8.mol

Synonyms:Methyl 4-broMo-2-chloro-5-fluorobenzoate;4-Bromo-2-chloro-5-fluoro-benzoic acid methyl ester

Chemical Property of Methyl 4-broMo-2-chloro-5-fluorobenzoate

Chemical Property:

• PSA: 26.30000
• LogP: 3.02820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-bromo-2-chloro-5-fluorobenzoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Methyl 4-broMo-2-chloro-5-fluorobenzoate

There total 2 articles about Methyl 4-broMo-2-chloro-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2-chloro-5-fluorobenzoic acid (177480-81-8) + acetyl chloride (75-36-5) → methyl 4-bromo-2-chloro-5-fluorobenzoate (908248-32-8)

Guidance literature:

In methanol; at 20 - 50 ℃;

DOI:10.1021/jm500610n

Reference yield: 92.0%

methanol (67-56-1) + 4-bromo-2-chloro-5-fluorobenzoic acid (177480-81-8) → methyl 4-bromo-2-chloro-5-fluorobenzoate (908248-32-8)

Guidance literature:

With thionyl chloride; In methanol; at 0 ℃; for 8h; Reflux;

Reference yield: 100.0%

methyl 4-bromo-2-chloro-5-fluorobenzoate (908248-32-8) → (4-bromo-2-chloro-5 fluoro-phenyl)-methanol (1338254-21-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; methanol; at 20 ℃; for 6h; Reflux;

upstream raw materials:

methanol

4-bromo-2-chloro-5-fluorobenzoic acid

acetyl chloride

Downstream raw materials:

(4-bromo-2-chloro-5 fluoro-phenyl)-methanol

1-bromo-5-chloro-4-((3,4-dichlorophenoxy)-methyl)-2-fluorobenzene

methyl 2-chloro-4-cyano-5-fluorobenzoate

2-chloro-4-cyano-5-fluorobenzamide

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