2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde

Base Information

• Chemical Name: 2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde
• CAS No.: 71128-83-1
• Molecular Formula: C10H10O3
• Molecular Weight: 178.188
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID80364192
• Nikkaji Number: J1.571.963J
• Wikidata: Q82148017
• Mol file: 71128-83-1.mol

Synonyms:2-methoxy-5-methylbenzene-1,3-dicarbaldehyde;71128-83-1;2-METHOXY-5-METHYLISOPHTHALALDEHYDE;2-Methoxy-5-methyl-benzene-1,3-dicarbaldehyde;SCHEMBL6737227;DTXSID80364192;AKOS000267893;CS-0241647;EN300-235736;F0848-0322

Chemical Property of 2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde

Chemical Property:

• Melting Point: 91.5-92.5 °C
• Boiling Point: 329.4±42.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 1.62860
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 178.062994177
• Heavy Atom Count: 13
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C=O)OC)C=O

Technology Process of 2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde

There total 6 articles about 2-Methoxy-5-methylbenzene-1,3-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Hydroxy-5-methylisophthalaldehyde (7310-95-4) + methyl iodide (74-88-4) → 2-methoxy-5-methyl-1,3-benzenedicarboxaldehyde (71128-83-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; for 21h;

DOI:10.1039/b102031p

Reference yield:

2,6-bis(hydroxymethyl)-4-methyl-anisole (6327-85-1) → 2-methoxy-5-methyl-1,3-benzenedicarboxaldehyde (71128-83-1)

Guidance literature:

With sodium dichromate; sulfuric acid;

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → 2-methoxy-5-methyl-1,3-benzenedicarboxaldehyde (71128-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH-solution

2: Na₂Cr₂O₇; diluted sulfuric acid

With sodium hydroxide; sodium dichromate; sulfuric acid;

upstream raw materials:

2,6-bis(hydroxymethyl)-4-methyl-anisole

2-Hydroxy-5-methylisophthalaldehyde

methyl iodide

2,6-bis(hydroxymethyl)-4-methylphenol

Downstream raw materials:

2,6-bis(hydroxymethyl)-4-methyl-anisole

C₃₂H₅₄O₃Si₂

meso-2,6-bis(-1-hydroxy-3-trimethylsilylprop-2-ynyl)-4-methyl-anisole

(3-Hydroxymethyl-2-methoxymethoxy-5-methyl-phenyl)-methanol