2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE

Base Information

• Chemical Name: 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE
• CAS No.: 726697-13-8
• Molecular Formula: C7H7Cl2N3
• Molecular Weight: 204.059
• Hs Code.: 2933990090
• Mol file: 726697-13-8.mol

Synonyms:2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE;Pyrido[4,3-d]pyriMidine, 2,4-dichloro-5,6,7,8-tetrahydro-, hydrochloride (1:1);Pyrido[4,3-d]pyrimidine,2,4-dichloro-5,6,7,8-tetrahydro-

Chemical Property of 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE

Chemical Property:

• Vapor Pressure: 3.46E-05mmHg at 25°C
• Boiling Point: 354°C at 760 mmHg
• PKA: 5.63±0.20(Predicted)
• Flash Point: 167.9°C
• PSA: 37.81000
• Density: 1.43g/cm³
• LogP: 1.75790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE

There total 1 articles about 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (726697-13-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 48 h / Reflux

2: trichlorophosphate / 3 h / Reflux

3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

With carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; trichlorophosphate; In methanol; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (726697-13-8) → N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate (1542711-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: acetonitrile / 12 h / 0 - 20 °C

With triethylamine; In dichloromethane; acetonitrile;

Reference yield:

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (726697-13-8) → C28H31N5O2 (1542711-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: acetonitrile / 12 h / 0 - 20 °C

3: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 0 - 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; acetonitrile;

upstream raw materials:

C₉H₁₄O₃NC₆H₅

Downstream raw materials:

N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

C₂₈H₃₁N₅O₂

N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 726697-13-8 2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send