N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

Base Information

Chemical Name:N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate
CAS No.:1542711-17-0
Molecular Formula:C₁₉H₂₃ClN₄O₂
Molecular Weight:374.87
Hs Code.:

Synonyms:N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

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Chemical Property of N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

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Technology Process of N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

There total 6 articles about N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 635698-56-5
tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 100-46-9
benzylamine

: 1542711-17-0
N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1542711-17-0
N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / methanol / 48 h / Reflux

2: trichlorophosphate / 3 h / Reflux

3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

4: triethylamine / dichloromethane / 2 h

5: triethylamine / acetonitrile / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; triethylamine; trichlorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 778574-06-4
6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

: 1542711-17-0
N-tert-butyl 4-(benzylamino)-2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 6 h / 0 - 100 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: acetonitrile / 12 h / 0 - 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; triethylamine; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;