1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

Base Information

Chemical Name:1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide
CAS No.:1542705-58-7
Molecular Formula:C₂₄H₂₄N₆O
Molecular Weight:412.494
Hs Code.:

Synonyms:1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

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Chemical Property of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

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Technology Process of 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

There total 16 articles about 1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: tert-butyl 4-(benzylamino)-2-(4-carbamoyl-2-methyl-1Hindol-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

: 1542705-58-7
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

Guidance literature:: With hydrogenchloride; In methanol; for 0.5h;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1542705-58-7
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium methylate / methanol / 48 h / Reflux

2: trichlorophosphate / 3 h / Reflux

3: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

4: triethylamine / dichloromethane / 2 h

5: triethylamine / acetonitrile / 20 °C

6: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

7: triphenylphosphine; palladium diacetate / ethanol / 2 h / Reflux

8: hydrogenchloride / methanol / 0.5 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; sodium methylate; palladium diacetate; caesium carbonate; triethylamine; triphenylphosphine; XPhos; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346

Reference yield:

: 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diol

: 1542705-58-7
1-(4-(benzylamino)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate / 3 h / Reflux

2: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 3 h / Reflux

3: triethylamine / dichloromethane / 2 h

4: triethylamine / acetonitrile / 20 °C

5: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 100 °C

6: triphenylphosphine; palladium diacetate / ethanol / 2 h / Reflux

7: hydrogenchloride / methanol / 0.5 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; palladium diacetate; caesium carbonate; triethylamine; triphenylphosphine; XPhos; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.5b01346