4-broMo-2-chloro-5-(trifluoroMethoxy)aniline

Base Information

• Chemical Name: 4-broMo-2-chloro-5-(trifluoroMethoxy)aniline
• CAS No.: 115844-00-3
• Molecular Formula: C7H4BrClF3NO
• Molecular Weight: 290.467
• Hs Code.: 9999999999
• Mol file: 115844-00-3.mol

Synonyms:4-broMo-2-chloro-5-(trifluoroMethoxy)aniline;4-bromo-2-chloro-5-(trifluoromethoxy)benzenamine

Chemical Property of 4-broMo-2-chloro-5-(trifluoroMethoxy)aniline

Chemical Property:

• Boiling Point: 245.7±35.0 °C(Predicted)
• PKA: 0.71±0.10(Predicted)
• PSA: 35.25000
• Density: 1.812±0.06 g/cm3(Predicted)
• LogP: 4.16450

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-chloro-5-(trifluoromethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-broMo-2-chloro-5-(trifluoroMethoxy)aniline

There total 1 articles about 4-broMo-2-chloro-5-(trifluoroMethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-bromo-3-(trifluoromethoxy)phenylamine (116369-25-6) → 4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine (115844-00-3)

Guidance literature:

With N-chloro-succinimide; In quinoclamine; ethyl acetate;

Reference yield: 60.0%

4-(piperazin-1-yl)piperidine-1-carboxylic acid tert-butyl ester (177276-41-4) + 4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine (115844-00-3) + 1,1'-carbonyldiimidazole (530-62-1) → 4-[4-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperazin-1-yl]piperidine-1-carboxylic acid tert-butyl ester (1477815-33-0)

Guidance literature:

4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; Inert atmosphere;

4-(piperazin-1-yl)piperidine-1-carboxylic acid tert-butyl ester; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield: 17.0%

4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine (115844-00-3) + (S)-3-methyl-4-(piperidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester (1477815-58-9) + 1,1'-carbonyldiimidazole (530-62-1) → (S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester (1477815-63-6)

Guidance literature:

4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

(S)-3-methyl-4-(piperidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; In dichloromethane; Inert atmosphere;

upstream raw materials:

4-bromo-3-(trifluoromethoxy)phenylamine

Downstream raw materials:

N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

(2S,4S)-2-{4-[5'-chloro-4'-({6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-pyridine-3-carbonyl}-amino)-2'-trifluoromethoxy-biphenyl-4-yl]-1H-imidazol-2-yl}-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(3-hydroxy-2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

(2S,4S)-2-{4-[5'-chloro-4'-({6-[(R)-4-(3-hydroxy-2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-pyridine-3-carbonyl}-amino)-2'-trifluoromethoxy-biphenyl-4-yl]-1H-imidazol-2-yl}-4-methoxy-pyrrolidine-1-carboxylic acid tert-butyl ester