N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

Base Information

• Chemical Name: N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide
• CAS No.: 1433280-30-8
• Molecular Formula: C₂₃H₂₅BrClF₃N₄O₃
• Molecular Weight: 577.829
• Mol file: 1433280-30-8.mol

Synonyms:N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

Chemical Property of N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

There total 5 articles about N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-((R)-2-methyl-piperazin-1-yl)-nicotinamide di-hydrochloride salt + pivaloyl chloride (3282-30-2) → N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide (1433280-30-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 20 ℃; for 1h;

Reference yield:

4-bromo-3-(trifluoromethoxy)phenylamine (116369-25-6) → N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide (1433280-30-8)

Guidance literature:

Multi-step reaction with 5 steps

1: N-chloro-succinimide / acetonitrile / 60 °C

2: N,N-dimethyl acetamide / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; N,N-dimethyl acetamide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; acetonitrile;

Reference yield:

4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine (115844-00-3) → N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide (1433280-30-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N,N-dimethyl acetamide / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 120 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1 h / 20 °C

With hydrogenchloride; N,N-dimethyl acetamide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;

upstream raw materials:

4-bromo-3-(trifluoromethoxy)phenylamine

4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine

pivaloyl chloride

N-(4-bromo-2-chloro-5-trifluoromethoxy-phenyl)-6-fluoro-nicotinamide

Downstream raw materials:

N-(5-chloro-4'-(2-((2S,4S)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-2-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)-6-((R)-2-methyl-4-pivaloylpiperazin-1-yl)nicotinamide

N-{5-chloro-4'-[2-((2S,4S)-4-methoxy-pyrrolidin-2-yl)-1H-imidazol-4-yl]-2-trifluoromethoxy-biphenyl-4-yl}-6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-nicotinamide

(2S,4S)-2-{4-[5'-chloro-4'-({6-[(R)-4-(2,2-dimethyl-propionyl)-2-methyl-piperazin-1-yl]-pyridine-3-carbonyl}-amino)-2'-trifluoromethoxy-biphenyl-4-yl]-1H-imidazol-2-yl}-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(R)-(5-chloro-4-(6-(2-methyl-4-pivaloylpiperazin-1-yl)nicotinamido)-2-(trifluoromethoxy)phenyl)boronic acid