4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol

Base Information

• Chemical Name: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol
• CAS No.: 1192765-29-9
• Molecular Formula: C11H15BO3
• Molecular Weight: 206.049
• Hs Code.: 2931900090
• Mol file: 1192765-29-9.mol

Synonyms:4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol;4-Hydroxybenzeneboronic acid, neopentyl glycol ester

Chemical Property of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol

Chemical Property:

• PSA: 38.69000
• LogP: 1.16040

Purity/Quality:

99%,98%, ^*data from raw suppliers

4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol acts as a reagent in the preparation of 3-hydroxy-5-arylisothiazole derivatives as GPR40 agonists.

Technology Process of 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol

There total 4 articles about 4-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

p-Iodophenol (540-38-5) + 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane (201733-56-4) → 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenol (1192765-29-9)

Guidance literature:

With bis-(dimethylamino)methane; In water; acetone; acetonitrile; at 20 ℃; for 4h; chemoselective reaction; UV-irradiation;

DOI:10.1039/c5sc04521e

Reference yield: 70.0%

(p-hydroxyphenyl)boronic acid (71597-85-8) + 2,2-Dimethyl-1,3-propanediol (126-30-7) → 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenol (1192765-29-9)

Guidance literature:

With 1H-imidazole; iron(III) chloride; In water; acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0033-1340500

Reference yield: 54.0%

4-chloro-phenol (106-48-9,82344-39-6) + 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane (201733-56-4) → 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenol (1192765-29-9)

Guidance literature:

With C₂₇H₄₁Br₂N₂NiO₃P; potassium methanolate; In 1,4-dioxane; at 40 ℃; for 6h; Inert atmosphere;

upstream raw materials:

5,5-dimethyl-1,3,2-dioxaborinane

4-chloro-phenol

(p-hydroxyphenyl)boronic acid

2,2-Dimethyl-1,3-propanediol

Downstream raw materials:

5-(4-((3-(6-(3-hydroxy-3-methylbutoxy)-4-methylpyridin-3-yl)-2-methylphenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide

4-(5-(3-((4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenoxy)methyl)-2-methylphenyl)-4-methylpyridin-2-yloxy)-2-methylbutan-2-ol

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