4'-Methoxy-3-(4-methylphenyl)propiophenone

Base Information

• Chemical Name: 4'-Methoxy-3-(4-methylphenyl)propiophenone
• CAS No.: 106511-65-3
• Molecular Formula: C17H18O2
• Molecular Weight: 254.329
• Hs Code.: 2914509090
• DSSTox Substance ID: DTXSID90483005
• Nikkaji Number: J2.344.776B
• Wikidata: Q82319929
• Mol file: 106511-65-3.mol

Synonyms:4'-METHOXY-3-(4-METHYLPHENYL)PROPIOPHENONE;106511-65-3;1-(4-METHOXYPHENYL)-3-(4-METHYLPHENYL)PROPAN-1-ONE;MFCD03843035;4/'-Methoxy-3-(4-methylphenyl)propiophenone;DTXSID90483005;AKOS016021528

Chemical Property of 4'-Methoxy-3-(4-methylphenyl)propiophenone

Chemical Property:

• Vapor Pressure: 7.15E-07mmHg at 25°C
• Boiling Point: 408.2°C at 760 mmHg
• Flash Point: 179.5°C
• PSA: 26.30000
• Density: 1.066g/cm³
• LogP: 3.81910
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 254.130679813
• Heavy Atom Count: 19
• Complexity: 271

Purity/Quality:

98%min ^*data from raw suppliers

4'-Methoxy-3-(4-methylphenyl)propiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)CCC(=O)C2=CC=C(C=C2)OC

Technology Process of 4'-Methoxy-3-(4-methylphenyl)propiophenone

There total 15 articles about 4'-Methoxy-3-(4-methylphenyl)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Methylbenzyl alcohol (589-18-4) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 3-(4-methylphenyl)-1-(4’-methoxyphenyl)propan-1-one (106511-65-3)

Guidance literature:

With potassium tert-butylate; C₃₅H₃₃Cl₂CoN₅O₂; In toluene; at 110 ℃; for 24h; Reagent/catalyst; Catalytic behavior; Inert atmosphere;

DOI:10.1039/d0dt03748f

Reference yield: 91.0%

1-(4-methoxyphenyl)cyclopropan-1-ol (15973-65-6) + 4-methylphenylboronic acid (5720-05-8) → 3-(4-methylphenyl)-1-(4’-methoxyphenyl)propan-1-one (106511-65-3)

Guidance literature:

With copper diacetate; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In water; dimethyl sulfoxide; at 70 ℃; for 2h; chemoselective reaction;

DOI:10.1021/acs.joc.0c00160

Reference yield: 91.0%

(E)-1-(4-methoxyphenyl)-3-p-tolylprop-2-en-1-one (41564-65-2) → 3-(4-methylphenyl)-1-(4’-methoxyphenyl)propan-1-one (106511-65-3)

Guidance literature:

With ammonium acetate; zinc; In ethanol; at 20 ℃; for 1.5h;

upstream raw materials:

3-(p-tolyl)propionyl chloride

methoxybenzene

4-Methylbenzyl alcohol

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

α-bromo-α,β-dihydro-4'-methoxy-4-methylchalcone

2-mercapto-4-(4'-methoxyphenyl)-5-(4''-methylphenylmethyl)thiazole

2-methylmercapto-4-(4'-methoxyphenyl)-5-(4''-methylphenylmethyl)thiazole

2-acetylamino-4-(4'-methoxyphenyl)-5-(4''-methylphenylmethyl)thiazole