Cyclopropanol, 1-(4-methoxyphenyl)-

Base Information

• Chemical Name: Cyclopropanol, 1-(4-methoxyphenyl)-
• CAS No.: 15973-65-6
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• European Community (EC) Number: 821-959-9
• DSSTox Substance ID: DTXSID00483697
• Nikkaji Number: J2.449.820D
• Wikidata: Q82321217
• Mol file: 15973-65-6.mol

Synonyms:15973-65-6;1-(4-methoxyphenyl)cyclopropan-1-ol;1-(4-methoxyphenyl)cyclopropanol;Cyclopropanol, 1-(4-methoxyphenyl)-;DTXSID00483697;AKOS011964827;EN300-358949

Chemical Property of Cyclopropanol, 1-(4-methoxyphenyl)-

Chemical Property:

• Boiling Point: 75-78 °C(Press: 0.5 Torr)
• PSA: 29.46000
• Density: 1.199±0.06 g/cm3(Predicted)
• LogP: 1.67660
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

99% ^*data from raw suppliers

1-(4-methoxyphenyl)cyclopropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2(CC2)O

Technology Process of Cyclopropanol, 1-(4-methoxyphenyl)-

There total 14 articles about Cyclopropanol, 1-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(benzenesulfonyl)cyclopropanol (1006613-82-6) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 1-(4-methoxyphenyl)cyclopropan-1-ol (15973-65-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 5h; Temperature; Solvent;

DOI:10.1021/acs.orglett.0c02303

Reference yield: 76.0%

1-bromo-4-methoxy-benzene (104-92-7) + cyclopropanone (5009-27-8) → 1-(4-methoxyphenyl)cyclopropan-1-ol (15973-65-6)

Guidance literature:

1-bromo-4-methoxy-benzene; With iodine; magnesium; In tetrahydrofuran; Inert atmosphere;

cyclopropanone; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.8b01225

Reference yield: 75.0%

methyl 4-methoxybenzoate (121-98-2) + ethylmagnesium chloride (2386-64-3) → 1-(4-methoxyphenyl)cyclopropan-1-ol (15973-65-6)

Guidance literature:

With titanium(IV) isopropylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol070159h

upstream raw materials:

1-(trimethylsilyloxy)1-(4-methoxyphenyl)cyclopropane

1,3-Dichloroacetone

4-methoxyphenyl magnesium bromide

Chloroiodomethane

Downstream raw materials:

1-(4-methoxyphenyl)cyclopropyl 3,5-dinitrobenzoate

3-azido-1-(4-methoxy-phenyl)-propan-1-one

α-Bromoethyl p-methoxaphenyl ketone

1,6-bis(4-methoxyphenyl)hexa-1,6-dione