N-Methyl-N-phenyl-beta-alanine ethyl ester

Base Information

• Chemical Name: N-Methyl-N-phenyl-beta-alanine ethyl ester
• CAS No.: 2003-76-1
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.26888
• Mol file: 2003-76-1.mol

Synonyms:N-Methyl-N-phenyl-beta-alanine ethyl ester;N-Methyl-N-[2-(ethoxycarbonyl)ethyl]aniline

Chemical Property of N-Methyl-N-phenyl-beta-alanine ethyl ester

Chemical Property:

• Boiling Point: 105-109℃ (0.2 Torr)
• PKA: 5.22±0.50(Predicted)
• Flash Point: 112.7±14.0℃
• Density: 1.052±0.06 g/cm3 (20 oC 760 Torr)

Purity/Quality:

97% ^*data from raw suppliers

ETHYL 3-[METHYL(PHENYL)AMINO]PROPANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Methyl-N-phenyl-beta-alanine ethyl ester

There total 4 articles about N-Methyl-N-phenyl-beta-alanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-methylaniline (100-61-8) + propynoic acid ethyl ester (623-47-2) → ethyl 3-(methyl(phenyl)amino)propanoate (2003-76-1)

Guidance literature:

With tin(II) trifluoromethanesulfonate; ethanol; In toluene; at 120 ℃; for 7h;

DOI:10.1002/adsc.201501088

Reference yield: 83.0%

N-methylaniline (100-61-8) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(methyl(phenyl)amino)propanoate (2003-76-1)

Guidance literature:

ammonium cerium(IV) nitrate; at 20 ℃; for 8h; ultrasonication;

DOI:10.1016/j.tetlet.2006.05.182

Reference yield: 64.0%

ethyl bromoacetate (105-36-2) + N-((1H-benzo(d)(1,2,3)triazol-1-yl)methyl)-N-methylaniline (15497-51-5) → ethyl 3-(methyl(phenyl)amino)propanoate (2003-76-1)

Guidance literature:

With chloro-trimethyl-silane; zinc; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/S0040-4020(98)00353-6

upstream raw materials:

N-methylaniline

ethyl acrylate

3,6-Di--1,2,5-trithia-cycloheptadien-dicarbonsaeure-(4,7)-diethylester

ethyl bromoacetate

Downstream raw materials:

1,1-diphenyl-3-methylanilinopropene

3-(N-methyl-anilino)-1,1-diphenyl-propan-1-ol