(9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate

Base Information

• Chemical Name: (9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate
• CAS No.: 147687-15-8
• Molecular Formula: C18H19NO3
• Molecular Weight: 297.354
• Hs Code.: 9999999999
• DSSTox Substance ID: DTXSID801192448
• Mol file: 147687-15-8.mol

Synonyms:147687-15-8;Fmoc-Sarcosinol;(9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate;N-Fmoc-N-methyl-ethanolamine;9H-fluoren-9-ylmethyl N-(2-hydroxyethyl)-N-methylcarbamate;Carbamic acid, (2-hydroxyethyl)methyl-, 9H-fluoren-9-ylmethyl ester;Fmoc-Sar-ol;SCHEMBL12665926;DTXSID801192448;MFCD03788643;AKOS012614342;CS-16818;CS-0104919;D76496;EN300-7069709;(9H-Fluoren-9-yl)methyl(2-hydroxyethyl)(methyl)carbamate;(9H-fluoren-9-yl)methyl N-(2-hydroxyethyl)-N-methylcarbamate;2-(9-Fluorenylmethyloxycarbonyl)aminomethyl-ethanol, N-(9-Fluorenylmethyloxycarbonyl)-sarcosinol

Chemical Property of (9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate

Chemical Property:

• Boiling Point: 474.2±24.0 °C(Predicted)
• PKA: 14.59±0.10(Predicted)
• PSA: 49.77000
• Density: 1.220±0.06 g/cm3(Predicted)
• LogP: 2.85960
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 297.13649347
• Heavy Atom Count: 22
• Complexity: 365

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-Sarcosinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCO)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of (9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate

There total 3 articles about (9H-Fluoren-9-yl)methyl (2-hydroxyethyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → N-Fmoc-N-methyl-2-aminoethanol (147687-15-8)

Guidance literature:

In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 97.0%

→ N-Fmoc-N-methyl-2-aminoethanol (147687-15-8)

Guidance literature:

Reference yield: 86.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → N-Fmoc-N-methyl-2-aminoethanol (147687-15-8)

Guidance literature:

In diethyl ether; at 20 ℃; for 2h;

DOI:10.1002/ejoc.200700646

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

(fluorenylmethoxy)carbonyl chloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

(Z)-5-[4-[2-[N-methyl-N-(pyridin-2-yl)amino]ethoxy]benzylidene]thiazolidine-2,4-dione

rosiglitazone

9-methylene-fluorene

C₇₀H₆₇N₅O₁₅