2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole

Base Information

• Chemical Name: 2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole
• CAS No.: 55315-33-8
• Molecular Formula: C₁₁H₈ClNO₂S
• Molecular Weight: 253.709
• Hs Code.: 2934100090
• Mol file: 55315-33-8.mol

Synonyms:2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole

Chemical Property of 2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole

Chemical Property:

• PSA: 59.59000
• LogP: 3.27760

Purity/Quality:

98%min ^*data from raw suppliers

2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole

There total 3 articles about 2-(1,3-Benzodioxol-5-yl)-4-(chloromethyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

benzo[1,3]dioxole-5-carbothioic acid amide (15884-65-8) + 1,3-Dichloroacetone (534-07-6) → 2-benzo[1,3]dioxol-5-yl-4-chloromethyl-thiazole (55315-33-8)

Guidance literature:

In toluene; Reflux;

DOI:10.1021/jm401643m

Reference yield:

piperonylonitrile (4421-09-4) → 2-benzo[1,3]dioxol-5-yl-4-chloromethyl-thiazole (55315-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; triethylamine; diammonium sulfide / water / 50 °C

2: toluene / Reflux

With pyridine; diammonium sulfide; triethylamine; In water; toluene;

DOI:10.1021/jm401643m

Reference yield:

→ 2-benzo[1,3]dioxol-5-yl-4-chloromethyl-thiazole (55315-33-8)

Guidance literature:

/BRN= 170598/;

upstream raw materials:

piperonylonitrile

benzo[1,3]dioxole-5-carbothioic acid amide

1,3-Dichloroacetone

Downstream raw materials:

5-(2-benzo[1,3]dioxol-5-yl-thiazol-4-ylmethyl)-1(2)H-tetrazole

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